{
  "contentStorage": "postgres",
  "title": "硖合宪三",
  "description": "硖合宪三（Kenso Soai，1950年—）是日本有机化学家，因发现不对称自催化反应（硖合反应）与亨利·卡根共享2026年诺贝尔化学奖，该反应为生命分子同手性起源提供了实验模型。",
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    "title": "硖合宪三",
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    ],
    "summary": "硖合宪三（Kenso Soai，1950年—）是日本有机化学家，因发现不对称自催化反应（硖合反应）与亨利·卡根共享2026年诺贝尔化学奖，该反应为生命分子同手性起源提供了实验模型。",
    "status": "published",
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      {
        "id": "s1",
        "title": "Kenso Soai – Facts",
        "author": "The Nobel Foundation",
        "url": "https://www.nobelprize.org/prizes/chemistry/2026/soai/facts/"
      },
      {
        "id": "s2",
        "title": "The Nobel Prize in Chemistry 2026",
        "author": "The Nobel Foundation",
        "url": "https://www.nobelprize.org/prizes/chemistry/2026/summary/"
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      {
        "id": "s3",
        "title": "2026年诺贝尔化学奖揭晓",
        "url": "https://news.sciencenet.cn/sbhtmlnews/2026/10/391530.shtm"
      },
      {
        "id": "s4",
        "title": "迟到25年！诺贝尔化学奖揭晓，95岁法国教授圆梦",
        "url": "https://www.qbitai.com/2026/10/501825.html"
      }
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    "createdAt": "2026-11-01T03:38:01+08:00",
    "updatedAt": "2026-11-02T12:26:33+08:00",
    "updatedBy": "user:admin",
    "revision": 5,
    "body": "**硖合宪三**（Kenso Soai，1950年—）出生于广岛市（日本）。\n\n## 获奖\n\n2026 年诺贝尔化学奖由 2 位得主共享，硖合宪三占其中 1/2 份，官方获奖理由（官方原文）：“for the discovery of non-linear effects and autocatalysis in asymmetric organic synthesis”[^s1]。获奖时所属机构为 Tokyo University of Science，所在地为东京都（日本）[^s1]。\n\n## 生平与职业生涯\n\n硖合宪三生于广岛市，长期任教于东京理科大学，获奖时为该校荣誉教授[^s3]。他从不对称合成的催化剂研究起步：先用氨基醇类催化剂实现吡啶甲醛与二异丙基锌的不对称加成，1990年发表了首例不对称自催化反应[^s4]。\n\n## 主要成就\n\n1995年，硖合团队在《自然》发表后来以他命名的硖合反应：手性嘧啶醇产物本身就是催化剂，能催化生成更多与自身手性相同的分子[^s4]。经过多轮循环，初始仅千万分之五量级的手性偏差可被放大到对映体过量99.5%以上，放大数十万倍[^s4]。这一结果表明，微小的初始手性偏向可通过正反馈变为绝对优势，为解释自然界氨基酸、糖类为何只用一种手性提供了关键化学模型[^s3]。2026年10月7日，瑞典皇家科学院宣布他与卡根共享当年诺贝尔化学奖[^s3]。\n\n## 参见\n\n[[work_nobel_prize_2026|2026 年诺贝尔奖]]、[[concept_nobel_prize|诺贝尔奖]]",
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      "names": {
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        "en": "Nobel Prize",
        "es": "Premio Nobel",
        "fr": "Prix Nobel",
        "ja": "ノーベル賞",
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      "descriptions": {
        "en": "Nobel prizes, their laureates, awarding bodies and yearly lists.",
        "zh": "诺贝尔奖各奖项、历年名单与相关人物、机构。"
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