{
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  "title": "阿夫拉姆·赫什科 · Relazioni",
  "description": "阿夫拉姆·赫什科是发现泛素介导蛋白质降解系统的生物化学家，2004年诺贝尔化学奖得主之一。",
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    "type": "person",
    "title": "阿夫拉姆·赫什科",
    "slug": "avram-hershko",
    "aliases": [
      "Avram Hershko"
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    "summary": "阿夫拉姆·赫什科是发现泛素介导蛋白质降解系统的生物化学家，2004年诺贝尔化学奖得主之一。",
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        "id": "s1",
        "title": "Avram Hershko – Facts",
        "author": "The Nobel Foundation",
        "url": "https://www.nobelprize.org/prizes/chemistry/2004/hershko/facts/"
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        "id": "s2",
        "title": "The Nobel Prize in Chemistry 2004",
        "author": "The Nobel Foundation",
        "url": "https://www.nobelprize.org/prizes/chemistry/2004/summary/"
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        "title": "阿夫拉姆·赫什科 – Biographical",
        "author": "The Nobel Foundation",
        "url": "https://www.nobelprize.org/prizes/chemistry/2004/hershko/biographical/"
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        "title": "阿夫拉姆·赫什科",
        "author": "Wikipedia",
        "url": "https://zh.wikipedia.org/wiki/%E9%98%BF%E5%A4%AB%E6%8B%89%E5%A7%86%C2%B7%E8%B5%AB%E4%BB%80%E7%A7%91"
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    "createdAt": "2026-11-01T03:38:01+08:00",
    "updatedAt": "2026-11-02T14:49:22+08:00",
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    "body": "**阿夫拉姆·赫什科**（Avram Hershko，1937年12月31日—）出生于考尔曹格（匈牙利）。\n\n## 生平与职业生涯\n\n赫什科在耶路撒冷希伯来大学获医学博士学位，长期任教于以色列理工学院，从事蛋白质降解研究。[^s3][^s4]\n\n## 主要成就\n\n赫什科与切哈诺沃、罗斯共同发现泛素介导的蛋白质降解系统，揭示细胞以泛素标记需降解蛋白并由蛋白酶体清除的机制。[^s3][^s4]\n\n## 获奖\n\n2004 年诺贝尔化学奖由 3 位得主共享，阿夫拉姆·赫什科占其中 1/3 份，官方获奖理由（官方原文）：“for the discovery of ubiquitin-mediated protein degradation”[^s1]。获奖时所属机构为 Technion - Israel Institute of Technology，所在地为海法（以色列）[^s1]。\n\n## 参见\n\n[[work_nobel_prize_2004|2004 年诺贝尔奖]]、[[concept_nobel_prize|诺贝尔奖]]",
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    "birth": {
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      "month": 12,
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