{
  "contentStorage": "postgres",
  "title": "坂口志文",
  "description": "坂口志文（Shimon Sakaguchi，1951年1月19日—）是日本免疫学家，2025 年诺贝尔生理学或医学奖得主之一。",
  "url": "/it/people/shimon-sakaguchi.html",
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    "title": "坂口志文",
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    "aliases": [
      "Shimon Sakaguchi"
    ],
    "summary": "坂口志文（Shimon Sakaguchi，1951年1月19日—）是日本免疫学家，2025 年诺贝尔生理学或医学奖得主之一。",
    "status": "published",
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    "tags": [
      "tag-nobel-prize"
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    "sources": [
      {
        "id": "s1",
        "title": "Shimon Sakaguchi – Facts",
        "author": "The Nobel Foundation",
        "url": "https://www.nobelprize.org/prizes/medicine/2025/sakaguchi/facts/"
      },
      {
        "id": "s2",
        "title": "The Nobel Prize in Physiology or Medicine 2025",
        "author": "The Nobel Foundation",
        "url": "https://www.nobelprize.org/prizes/medicine/2025/summary/"
      }
    ],
    "createdAt": "2026-11-01T03:38:01+08:00",
    "updatedAt": "2026-11-02T11:30:53+08:00",
    "updatedBy": "user:admin",
    "revision": 4,
    "body": "**坂口志文**（Shimon Sakaguchi，1951年1月19日—）出生于长滨市（日本）。\n\n## 获奖\n\n2025 年诺贝尔生理学或医学奖由 3 位得主共享，坂口志文占其中 1/3 份，官方获奖理由（官方原文）：“for their discoveries concerning peripheral immune tolerance”[^s1]。获奖时所属机构为 The University of Osaka，所在地为大阪市（日本）[^s1]。\n\n## 生平与贡献\n\n坂口志文是日本免疫学家。他发现并阐明了调节性 T 细胞（Treg）的作用：这类 T 细胞能够抑制过度的免疫反应，维持机体对自身组织的免疫耐受，防止自身免疫病的发生；他还参与阐明了转录因子 Foxp3 在调节性 T 细胞发育中的关键作用[^s1][^s2]。2025 年诺贝尔生理学或医学奖由他与玛丽·布伦科、弗雷德·拉姆斯德尔共享[^s2]。\n\n## 参见\n\n[[work_nobel_prize_2025|2025 年诺贝尔奖]]、[[concept_nobel_prize|诺贝尔奖]]",
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    "birth": {
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      "display": "1951年1月19日"
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    "occupations": [
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      "name": "Nobel Prize",
      "description": "Nobel prizes, their laureates, awarding bodies and yearly lists.",
      "names": {
        "de": "Nobelpreis",
        "en": "Nobel Prize",
        "es": "Premio Nobel",
        "fr": "Prix Nobel",
        "ja": "ノーベル賞",
        "ko": "노벨상",
        "ru": "Нобелевская премия",
        "zh": "诺贝尔奖",
        "zh-hant": "諾貝爾獎"
      },
      "descriptions": {
        "en": "Nobel prizes, their laureates, awarding bodies and yearly lists.",
        "zh": "诺贝尔奖各奖项、历年名单与相关人物、机构。"
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      "count": 1022
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      "listTitle": "2025 年诺贝尔奖",
      "listUrl": "/it/works/nobel-prize-2025.html",
      "edition": "2025",
      "name": "坂口志文",
      "tier": "medicine",
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