{
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  "title": "德鲁·魏斯曼",
  "description": "德鲁·魏斯曼（Drew Weissman，1959年9月7日—）是2023 年诺贝尔生理学或医学奖得主之一。",
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    "summary": "德鲁·魏斯曼（Drew Weissman，1959年9月7日—）是2023 年诺贝尔生理学或医学奖得主之一。",
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        "title": "Drew Weissman – Facts",
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        "url": "https://www.nobelprize.org/prizes/medicine/2023/weissman/facts/"
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        "title": "The Nobel Prize in Physiology or Medicine 2023",
        "author": "The Nobel Foundation",
        "url": "https://www.nobelprize.org/prizes/medicine/2023/summary/"
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        "title": "德鲁·韦斯曼 - 维基百科",
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    "updatedAt": "2026-11-02T14:49:00+08:00",
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    "body": "**德鲁·魏斯曼**（Drew Weissman，1959年9月7日—）出生于列克星敦（美国）。\n\n## 生平与职业生涯\n\n德鲁·魏斯曼在波士顿大学获得医学博士和哲学博士学位，先在美国国立卫生研究院工作，1997年转入宾夕法尼亚大学佩雷尔曼医学院，创建自己的实验室，主攻RNA与先天免疫系统生物学，现任该校宾夕法尼亚RNA创新研究所主任[^s3]。\n\n## 主要成就\n\n魏斯曼与卡塔林·卡里科合作发现，用修饰核苷（例如假尿苷）替代mRNA中的尿苷，可以避免未修饰mRNA引发的强烈炎症反应，同时提高目标蛋白的产量；结合脂质纳米颗粒递送技术，修饰mRNA成为安全有效的疫苗平台。2005年报告的这一突破直接奠定了辉瑞/BioNTech与莫德纳新冠mRNA疫苗的基础[^s1][^s3]。\n\n## 获奖\n\n2023 年诺贝尔生理学或医学奖由 2 位得主共享，德鲁·魏斯曼占其中 1/2 份，官方获奖理由（官方原文）：“for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19”[^s1]。获奖时所属机构为 Penn Institute for RNA Innovations, University of Pennsylvania，所在地为费城（美国）[^s1]。\n\n## 参见\n\n[[work_nobel_prize_2023|2023 年诺贝尔奖]]、[[concept_nobel_prize|诺贝尔奖]]",
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        "en": "Nobel Prize",
        "es": "Premio Nobel",
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